منابع مشابه
Bioenergetics Aging Clock
The theory of replicative senescence is based on the doubtless fact that cells of higher eukaryotes enter a non-dividing but viable state after a certain number of duplications, called the Hayflick limit. It is assumed that the accumulation of non-dividing cells in tissues leads finally to organism degradation [1], which is the leading cause of aging. The mechanism is that the ends of eukaryoti...
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The average lifespan of people in developed countries has tripled since ancient times while its maximum longevity (about 120 years) has remained invariable. The strategic goal of gerontology is to exceed this limit, i.e. to develop remedies which would allow the living of an indefinitely long life. However there have not been any significant advances in solving this problem so far. There is sti...
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Mitochondria have been a central focus of several theories of aging as a result of their critical role in bioenergetics, oxidant production, and regulation of cell death. A decline in cardiac mitochondrial function coupled with the accumulation of oxidative damage to macromolecules may be causal to the decline in cardiac performance with age. In contrast, regular physical activity and lifelong ...
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More than half of the elderly in today's society suffer from sleep disorders with detrimental effects on brain function, behavior, and social life. A major contribution to the regulation of sleep stems from the circadian system. The central circadian clock located in the suprachiasmatic nucleus of the hypothalamus is like other brain regions subject to age-associated changes. Age affects differ...
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At present, the etiology of idiopathic pulmonary fibrosis (IPF) remains elusive. Over the past two decades, however, researchers have identified and described the underlying processes that result in metabolic dysregulation, metabolic reprogramming, and mitochondrial dysfunction observed in the cells of IPF lungs. Metabolic changes and mitochondrial dysfunction in IPF include decreased efficienc...
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ژورنال
عنوان ژورنال: Bioenergetics: Open Access
سال: 2016
ISSN: 2167-7662
DOI: 10.4172/2167-7662.1000143